Adam is a research scientist at Barrow Neurological Institute interested in the role of glia in the pathogenesis of neurodegeneration.

The goal of my work is to investigate the links between environmental toxicant exposure, neuroinflammation, and neurodegeneration. I do this using comparative modeling and glial “phenomics” by integrating spatially mapped cellular morphometric data with epigenetic and transcriptomic profiles. This allows the determination of dynamic reactivity states throughout the initiation and progression of Alzheimer’s or Parkinson’s disease sequelae.

Toxicoepigenetics

Simulated Wildfire Smoke Significantly Alters Sperm DNA Methylation Patterns in a Murine Model

Treadmill training induces sex-dependent changes in hippocampal epigenetic patterns and plaque-associated microglial morphology in aged TgF344 rats

Transcriptomics

Simulated wildfire smoke particulate matter elicits STING-dependent astrocyte-mediated inflammatory signaling and neurotoxicity

Robust differential gene expression patterns in the prefrontal cortex of male mice exposed to an occupationally relevant dose of laboratory-generated wildfire smoke

Exposure Assessment

Indoor Air Quality Considerations for Laboratory Animals in Wildfire-Impacted Regions